A. Specialization of skills and methods of production: Large-scale manufacturing industries often involve specialized skills and techniques to efficiently produce goods on a significant scale. Workers are trained in specific tasks, and production processes are optimized for specialization.

B. Technological innovation: Modern manufacturing industries heavily rely on technological advancements to improve efficiency, product quality, and production capacity. Continuous technological innovation is essential for staying competitive.

C. Easy to establish: This option is not considered correct because large-scale manufacturing industries typically require significant capital investments, infrastructure, and resources. They are not typically "easy" to establish due to the complexities involved.

D. Organizational structure and stratification: Large-scale manufacturing industries often have complex organizational structures with hierarchical layers and divisions of labor. This is necessary to manage large workforces and production processes efficiently.

So, based on the characteristics of large-scale manufacturing industries, option 2 (A, B, D only) is the correct choice.